更多“免疫逃避immune evasion”相关问题
  • 第1题:

    有些寄生虫侵入免疫功能正常的宿主体内后,能逃避宿主的免疫攻击而继续生存、发育、繁殖,这种现象称为免疫逃避。免疫逃避的机制包括2个方面,即源于宿主的免疫逃避和源于寄生虫的免疫逃避。封闭抗体属于的免疫逃避机制为A、抗原变异

    B、抗体变异

    C、抑制宿主的免疫应答

    D、抗原伪装

    E、抗体伪装

    非洲锥虫有顺序地更换其表面糖蛋白,其免疫逃避机制为A、抗原变异

    B、抗体变异

    C、分子模拟

    D、抗原伪装

    E、抗体伪装


    参考答案:问题 1 答案:C


    问题 2 答案:A

  • 第2题:

    共用题干
    第一篇

    Immune Functions

    The immune system is equal in complexity to the combined intricacies of the brain and nervous system.
    The success of the immune system in defending the body relies on a dynamic regulatory communication net-
    work consisting of millions and millions of cells.Organized into sets and subsets,these cells pass information
    back and forth like clouds of bees flying around a hive(蜂巢).The result is a sensitive system of checks and
    balances that produces an immune response that is prompt,appropriate,effective,and self-limiting.
    At the heart of the immune system is the ability to distinguish between self and nonself. When immune
    defenders encounter cells or organisms carrying foreign or nonself molecules,the immune troops move quickly
    to eliminate the intruders(人侵者).Virtually every body cell carries distinctive molecules that identify it as
    self. The body's immune defenses do not normally attack tissues that carry a self-marker. Rather,immune
    cells and other body cells coexist peaceably in a state known as self-tolerance.When a normally functioning
    immune system attacks a nonself molecule,the system has the ability to"remember"the specifics of the
    foreign body.Upon subsequent encounters with the same species of molecules,the immune system reacts
    accordingly. With the possible exception of antibodies(抗体)passed during lactation(授乳期), this so
    called immune system memory is not inherited.Despite the occurrence of a virus in your family,your immune
    system must"learn"from experience with the many millions of distinctive nonseif molecules in the sea of
    microbes(微生物)in which we live. Learning entails producing the appropriate molecules and cells to match
    up with and counteract each nonseif invader.
    Any substance capable of triggering an immune response is called an antigen(抗原).Antigens are not
    to be confused with illergens(过敏原),which are most often harmless substances that provoke the immune
    system to set off the inappropriate and harmful response known as allergy.An antigen can be a virus,a bacte-
    rium,or even a portion or product of one of these organisms.Tissues or cells from another individual also act
    as antigens,because the immune system recognizes transplanted tissues as foreign,it rejects them.The body
    will even reject nourishing proteins unless they are first broken down by the digestive system into their
    primary,nonantigenic building blocks.An antigen announces its foreignness by means of intricate and charac-
    teristic shapes called epitopes(抗原表位), which protrude(突出)from its surface. Most antigens , even the
    simplest microbes,carry several different kinds of epitopes on their surface;some may even carry several
    hundreds.Some epitopes will be more effective than others at stimulating an immune response.Only in abnormal
    situations does the immune system wrongly identify self as nonself and execute a misdirected immune attack.

    What is used to describe the communication network consisting of cells in the immune system?
    A:The immune system's memory.
    B:Immune troops sliminating intruders.
    C:Bees flying around a hive.
    D:A sea of microbes.

    答案:C
    解析:
    由第一段第三句中的“like clouds of bees flying around a hive”可知选B。
    由文章第二段第五句可知答案为A。
    由文章最后一段中的“An antigen announces its foreignness by …characteristic shapes …" 可知选C。
    由文章最后一段第一句可知,能引起免疫反应的物质叫抗原,即抗原能引起免疫反应, 故选B
    由文章第二段第一句“At the heart of the immune system...”可知选D。 heart相当 于basic。

  • 第3题:

    简述免疫逃避机制。


    正确答案: 1.组织学隔离
    2.表面抗原改变或伪装
    (1)抗原变异;
    (2)分子模拟与伪装;
    (3)表膜脱落与更新。
    3.抑制宿主的免疫应答
    (1)特异性B细胞克隆的耗竭;
    (2)抑制性T细胞(Ts)的激活;
    (3)分泌虫源性淋巴细胞毒性因子;
    (4)封闭抗体的产生。

  • 第4题:

    免疫逃避


    正确答案: 免疫逃避有些寄生虫在与宿主长期相互适应过程中,能逃避宿主的免疫效应,并能在宿主体内存活和增殖,称为寄生虫的免疫逃避。免疫逃避的机制主要有:抗原性改变(抗原变异、分子模拟与伪装、表膜脱落与更新),组织学隔离和抑制或直接破坏宿主的免疫应答。

  • 第5题:

    免疫应答(immune response)


    正确答案: 免疫应答是机体免疫系统对抗原刺激所产生的以排除抗原为目的的生理过程。免疫应答的过程可以人为地分成三个阶段:抗原识别阶段、淋巴细胞活化阶段、抗原清除阶段。

  • 第6题:

    简述肿瘤免疫逃避机制。


    正确答案:(1)免疫抑制:机体中的调节性T细胞是一群具有免疫抑制作用的T细胞亚群。肿瘤细胞可以吸引调节性T细胞,也可以分泌TGF-β、IL-10等细胞因子诱导初始CD4+T细胞转化为调节性T细胞。同时这些细胞因子对树突状细胞、细胞毒性T细胞的功能起抑制作用。
    (2)免疫耐受:肿瘤细胞逃避免疫监视可能是有由于缺乏某一种或几种成分,导致肿瘤细胞免疫耐受。肿瘤细胞表面的MHC-Ⅰ类分子表达程度与正常细胞相比有不同程度的降低,可以避免CTL攻击。

  • 第7题:

    免疫逃避的机制是什么?


    正确答案: 寄生虫抗原性改变,组织性隔离,抑制宿主的免疫应答,释放可溶性抗原,代谢抑制。

  • 第8题:

    何谓寄生虫的免疫逃避?


    正确答案: 某些寄生虫在与宿主长期相互适应的过程中,产生了逃避宿主免疫攻击的能力,并能在宿主体内增殖或长期生存,这种现象称之为免疫逃避。其机制非常复杂,因不同寄生虫而异,可有如下原因:
    ①抗原变异。
    ②抗原伪装。
    ③抑制或干扰宿主的免疫应答。
    ④解剖位置的隔离。例如,寄生虫寄生于血管或淋巴管以外的部位如眼、脑、胚胎等处,受到较少的免疫攻击。

  • 第9题:

    名词解释题
    肿瘤细胞免疫逃避机制。

    正确答案: 肿瘤的免疫逃逸机制:取决于机体和肿瘤两方面的因素:
    (1)与肿瘤细胞有关的因素:①肿瘤细胞缺乏激发机体免疫应答所必需的有效抗原表位,不能有效诱发机体免疫应答;②肿瘤细胞MHC分子表达异常,影响抗原递呈作用;③肿瘤细胞不能正常表达活化免疫细胞的共刺激分子和粘附分子;④肿瘤细胞抗调亡或诱导免疫细胞凋亡;⑤肿瘤细胞产生细胞因子直接或间接抑制机体免疫功能。
    (2)与宿主免疫系统有关的因素:宿主处于免疫功能低下或对肿瘤细胞免疫耐受;宿主抗原提呈细胞功能缺陷;宿主体内存在一定量的“增强抗体”或免疫抑制因子。
    解析: 暂无解析

  • 第10题:

    名词解释题
    法律规避(evasion of law)

    正确答案: 是指涉外民事法律关系的当事人为利用某一冲突规范,故意制造某种连结点的客观事实,以避免本应适用的法律,从而使对自己有利的法律得以适用的一种逃法或脱法行为。
    解析: 暂无解析

  • 第11题:

    单选题
    这种现象临床上称(  )。
    A

    免疫失败

    B

    免疫应答

    C

    免疫耐受

    D

    免疫逃避

    E

    免疫不当


    正确答案: B
    解析:
    免疫失败是机体免疫过程中,由于某一种或某几种原因造成接种疫苗后群体或个体未达到预期免疫效果,而呈现的一种不健康状态的表现形式。从狭义上说,疫苗接种过的动物机体不产生相应的免疫应答或显著减弱,并由此造成不能预防相应疫病的现象称为免疫失败。猪瘟免疫失败的原因很多,通常认为有以下,可能:①疫苗保管条件和使用过程不规范;②免疫程序不合理;③饲料霉变或营养价值不全面;④其他免疫抑制疾病的发生,如猪繁殖与呼吸综合征、圆环病毒2型感染。

  • 第12题:

    问答题
    简述寄生虫免疫逃避的机制?

    正确答案: (1)抗原变异、隐蔽和脱落:A.抗原变异;B.分子模拟与伪装或隐蔽;C.表膜脱落与更新。
    (2)释放可溶性抗原。
    (3)解剖位置的隔离:在组织、消化道或细胞内寄生,避开了宿主抗体和致敏淋巴细胞的杀伤作用。
    (4)抑制宿主的免疫。
    解析: 暂无解析

  • 第13题:

    机体抗细胞内细菌感染免疫属于

    A、细胞免疫

    B、体液免疫

    C、被动免疫

    D、免疫逃避

    E、免疫抑制


    参考答案:A

  • 第14题:

    共用题干
    第一篇

    Immune Functions

    The immune system is equal in complexity to the combined intricacies of the brain and nervous system.
    The success of the immune system in defending the body relies on a dynamic regulatory communication net-
    work consisting of millions and millions of cells.Organized into sets and subsets,these cells pass information
    back and forth like clouds of bees flying around a hive(蜂巢).The result is a sensitive system of checks and
    balances that produces an immune response that is prompt,appropriate,effective,and self-limiting.
    At the heart of the immune system is the ability to distinguish between self and nonself. When immune
    defenders encounter cells or organisms carrying foreign or nonself molecules,the immune troops move quickly
    to eliminate the intruders(人侵者).Virtually every body cell carries distinctive molecules that identify it as
    self. The body's immune defenses do not normally attack tissues that carry a self-marker. Rather,immune
    cells and other body cells coexist peaceably in a state known as self-tolerance.When a normally functioning
    immune system attacks a nonself molecule,the system has the ability to"remember"the specifics of the
    foreign body.Upon subsequent encounters with the same species of molecules,the immune system reacts
    accordingly. With the possible exception of antibodies(抗体)passed during lactation(授乳期), this so
    called immune system memory is not inherited.Despite the occurrence of a virus in your family,your immune
    system must"learn"from experience with the many millions of distinctive nonseif molecules in the sea of
    microbes(微生物)in which we live. Learning entails producing the appropriate molecules and cells to match
    up with and counteract each nonseif invader.
    Any substance capable of triggering an immune response is called an antigen(抗原).Antigens are not
    to be confused with illergens(过敏原),which are most often harmless substances that provoke the immune
    system to set off the inappropriate and harmful response known as allergy.An antigen can be a virus,a bacte-
    rium,or even a portion or product of one of these organisms.Tissues or cells from another individual also act
    as antigens,because the immune system recognizes transplanted tissues as foreign,it rejects them.The body
    will even reject nourishing proteins unless they are first broken down by the digestive system into their
    primary,nonantigenic building blocks.An antigen announces its foreignness by means of intricate and charac-
    teristic shapes called epitopes(抗原表位), which protrude(突出)from its surface. Most antigens , even the
    simplest microbes,carry several different kinds of epitopes on their surface;some may even carry several
    hundreds.Some epitopes will be more effective than others at stimulating an immune response.Only in abnormal
    situations does the immune system wrongly identify self as nonself and execute a misdirected immune attack.

    The immune cells and other cells in the body coexist peaceably in a state known as________.
    A:self-tolerance
    B:balance
    C:harmony
    D:tolerance

    答案:A
    解析:
    由第一段第三句中的“like clouds of bees flying around a hive”可知选B。
    由文章第二段第五句可知答案为A。
    由文章最后一段中的“An antigen announces its foreignness by …characteristic shapes …" 可知选C。
    由文章最后一段第一句可知,能引起免疫反应的物质叫抗原,即抗原能引起免疫反应, 故选B
    由文章第二段第一句“At the heart of the immune system...”可知选D。 heart相当 于basic。

  • 第15题:

    HIV免疫逃避不能封闭人体免疫反应


    正确答案:错误

  • 第16题:

    适应性免疫应答(adaptive immune response)


    正确答案: 也称特异性免疫应答,是在非特异性免疫基础上建立的,该种免疫是个体在生命过程中接受抗原性异物刺激后,主动产生或接受免疫球蛋白分子后被动获得的。

  • 第17题:

    简述寄生虫免疫逃避的机制。


    正确答案: (1)解剖部位的隔离,如寄生在巨噬细胞内的弓形虫,可在胞内形成纳虫空泡,从而逃避细胞内溶酶体酶的杀伤作用;
    (2)表面抗原的改变,包括抗原变异、分子模拟与伪装和表膜的脱落与更新,如锥虫表面的糖蛋白可不断更新,从而逃避宿主的免疫攻击;
    (3)抑制宿主的免疫应答,有些寄生虫感染可通过各种方式诱导宿主产生免疫抑制,如血吸虫感染可通过抑制性T细胞的激活产生免疫抑制。

  • 第18题:

    免疫逃避抗原改变表现在抗原变异,抗原伪装。


    正确答案:错误

  • 第19题:

    固有免疫应答(innate immune response)


    正确答案: 也称非特异性或获得性免疫应答,是生物体在长期种系发育和进化过程中逐渐形成的一系列防御机制。此免疫在个体出生时就具备,可对外来病原体迅速应答,产生非特异性抗感染免疫作用,同时在特异性免疫应答过程中也起作用。

  • 第20题:

    单选题
    且有免疫逃避现象,可在细胞内有效逃避宿主免疫反应的是()
    A

    旋毛虫

    B

    囊尾蚴

    C

    棘球蚴

    D

    蛔虫幼虫

    E

    利什曼原虫


    正确答案: B
    解析: 暂无解析

  • 第21题:

    单选题
    机体抗细胞内细菌感染免疫属于()
    A

    细胞免疫

    B

    体液免疫

    C

    被动免疫

    D

    免疫逃避

    E

    免疫抑制


    正确答案: A
    解析: 暂无解析

  • 第22题:

    名词解释题
    交叉免疫反应(cross immune reaction)

    正确答案: 某些病原微生物的抗原与自身组织成分有共同抗原性,因此机体在感染这些微生物后,所产生的抗体或致敏的淋巴细胞对自身组织也可产生免疫反应,称为交叉免疫反应。
    解析: 暂无解析

  • 第23题:

    判断题
    HIV免疫逃避不能封闭人体免疫反应
    A

    B


    正确答案:
    解析: 暂无解析